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Reversing an adult opioid overdose with naloxone

18 October 2022A patient safety alert highlighted the risks of giving inappropriate doses of naloxone. We guide on using appropriate intravenous doses in the medical setting.

Managing constipation in people taking clozapine

14 October 2022Constipation in people taking clozapine can be fatal. Guidance on preventing and managing constipation in these individuals is described.

Managing peripheral oedema caused by calcium channel blockers

26 September 2022All calcium channel blockers may cause peripheral oedema. There are different treatment options and the incidence can be affected by different factors.

Assuring Investigational Medicinal Product (IMP) supply

22 September 2022Sponsor pharmacy role regarding the supply assurance of Investigational Medicinal Products (IMPs) in CTIMPs

Using intravenous paracetamol preparations safely in paediatrics

21 September 2022Safety risks and mitigation strategies are described to reduce the risk of errors with intravenous paracetamol in neonates, infants, and children.

Diagnosis and Medical Management of Acute CAR-T Cell Toxicities in Adults

16 September 2022Consensus guidance (involving Wave 1 and 2 CAR-T centres) on the management of acute CAR-T cell toxicities.

Operational Implications of UK Exit from the EU for NHS Clinical Trial Sites

16 September 2022A summary of the implications of the UKs exit from the EU for clinical trial sites for both IMP and ATIMPs, including supply to and from Northern Ireland

Safety considerations when using Vitamin D

7 September 2022Healthcare professionals who use vitamin D should be aware of the risks of toxicity and safe practice principles which may prevent patient harm

Metolazone preparation differences and safety considerations

7 September 2022Healthcare professionals involved in the use of metolazone need to be aware of the differences between licensed and unlicensed products to ensure safe care.

Outsourcing the Receipt, Storage, Preparation and Onward Supply of Marketed Cryopreserved ATMPs - A Template Technical Agreement

26 August 2022A template Quality Technical Agreement for Outsourcing the Receipt, Storage, Preparation and Onward Supply of Marketed Cryopreserved ATMPs.