Licensed for intrathecal use
Products licensed for intrathecal use are the first line option and should be used wherever suitable.
There are currently no known morphine products licensed for intrathecal administration.
Not licensed for intrathecal use, limited information available
Products with partial information that are not licensed for intrathecal administration can still sometimes be used. Refer to the advice in our article and complete a risk assessment to enable you to interpret the details below and choose an appropriate product.
AS KALCEKS (Latvia)
Strength
10 mg/mL in 1mL ampoules
15 mg/mL in 1mL ampoules
30 mg/mL in 1mL ampoules
Excipients
Sodium chloride, hydrochloric acid (for pH adjustment), water for injection
Osmolarity
No information
pH
No information
Endotoxin content
No information
Aurum
Strength
1mg/mL 50mL or 100mL vials
2mg/mL 50mL or 100mL vials
Excipients
Sodium chloride, water for injections
Osmolarity
No information
pH
No information
Endotoxin content
No information
Hameln
Strength
Excipients
Sodium chloride, hydrochloric acid, water for injections
Osmolarity
270 – 310 mOsmol/kg
pH
3.2 – 3.8
Endotoxin content
< 12 EU/mg
Strength
Excipients
Sodium chloride, hydrochloric acid, water for injection, nitrogen
Osmolarity
270 – 310 mOsmol/kg
pH
3.4 – 3.8
Endotoxin content
< 12 EU/mg
Macarthys t/a Martindale Pharm
Strength
10 mg/mL in 1mL ampoules
15 mg/mL in 1mL ampoules
20 mg/mL in 1mL ampoule
30 mg/mL in 1mL ampoule
Excipients
Sodium chloride, sodium metabisulfite (E223), water for injection
The pH may be adjusted with sodium hydroxide or sulfuric acid solution
Osmolarity
No information
pH
2.5 – 4.5
Endotoxin content
No information
Torbay & South Devon NHS Foundation Trust
Strength
1 mg/mL in 1mL, 5mL or 10mL ampoules, or 50mL vials
Excipients
Sodium Chloride, water for injection
Osmolarity
288 mOsmol/L
pH
4.0 – 6.5
Endotoxin content
≤ 17 EU/mL
Strength
Excipients
Sodium chloride, water for injection
Osmolarity
291 mOsmol/L
pH
4.0 – 6.5
Endotoxin content
≤ 34 IU/mL
Wockhardt
Strength
10 mg/mL in 1mL ampoules
15 mg/mL in 1mL ampoules
30 mg/mL in 1mL or 2mL ampoules
Excipients
Water for injection, sodium metabisulfite, sodium hydroxide, hydrochloric acid
Osmolarity
No information
pH
3.0 – 5.0
Endotoxin content
No information
Unlicensed ‘Special’, specified for intrathecal use
Unlicensed medicines that are manufactured in MHRA-licensed Specials Manufacturing Units, at the request of an authorised healthcare professional specifically for intrathecal use.
Torbay PMU
Morphine Sulfate Intrathecal Injection
Strength
300mg in 10mL
Update history
- Title and URL shortened.
- Updated Aurum links
- Removed Aurum pre-filled syringes
- Published