Licensed for intrathecal use
Products licensed for intrathecal use are the first line option and should be used wherever suitable.
There are currently no known hydrocortisone products licensed for intrathecal administration.
Not licensed for intrathecal use, limited information available
Products with partial information that are not licensed for intrathecal administration can still sometimes be used. Refer to the advice in our article and complete a risk assessment to enable you to interpret the details below and choose an appropriate product.
Amdipharm/ADVANZ (Efcortesol®)
Hydrocortisone sodium phosphate
Strength
100mg/mL in 1mL ampoules
100mg/mL in 5mL ampoules
Excipients
Disodium Edetate, disodium hydrogen phosphate (anhydrous), sodium acid phosphate, sodium formaldehyde bisulphite monohydrate, phosphoric acid (10% solution), water for injection
Osmolarity
No information
pH
7.5 – 8.5
Endotoxin content
≤ 70 IU/ml
Panpharma
Hydrocortisone sodium succinate
Strength
Excipients
Sodium hydrogen phosphate buffer
Osmolarity
260 – 292 mOsmol/kg
pH
7.0 – 8.0 (100mg in 2mL water for injection)
Endotoxin content
No information
Pfizer (Solu-Cortef®)
Hydrocortisone sodium succinate
Strength
Excipients
Sodium biphosphate, sodium phosphate
Osmolarity
260 – 292 mOsmol/kg
pH
7.0 – 8.0 (100mg in 2mL water for injection)
Endotoxin content
No information
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