Licensed for intrathecal use
Products licensed for intrathecal use are the first line option and should be used wherever suitable.
Accord
Strength
20 mg/mL in 2mL vial
20 mg/mL in 5mL vial
Hospira
Strength
20 mg/mL in 5mL vial
20 mg/mL in 25mL vial
20 mg/mL in 50mL vial
Not licensed for intrathecal use, limited information available
Products with partial information that are not licensed for intrathecal administration can still sometimes be used. Refer to the advice in our article and complete a risk assessment to enable you to interpret the details below and choose an appropriate product.
Accord
Strength
100 mg/mL in 1mL vial
100 mg/mL in 5mL vial
100 mg/mL in 10mL vial
100 mg/mL in 20mL vial
100 mg/mL in 40mL vial
100 mg/mL in 50mL vial
Excipients
Macrogol 400, trometamol (for pH adjustment), water for injection
Osmolarity
No information
pH
7.0 – 9.5
Endotoxin content
≤ 0.07 EU/mg
Fresenius
Strength
100 mg/mL in 1mL vial
100 mg/mL in 5mL vial
100 mg/mL in 10mL vial
100 mg/mL in 20mL vial
Excipients
Hydrochloric acid (for pH adjustment), sodium hydroxide (for pH adjustment), water for injection
Osmolarity
250 – 400 mOsmol/L
pH
7.0 – 9.5
Endotoxin content
No information
Hospira
Strength
100 mg/mL in 1mL vial
100 mg/mL in 5mL vial
100 mg/mL in 10mL vial
100 mg/mL in 20mL vial
Excipients
Water for injection, hydrochloric acid (for pH adjustment), sodium hydroxide (for pH adjustment)
SmPC (04/2021): Cytarabine 100 mg/ml Injection should not be administered by the intrathecal route due to the slight hypertonicity of this formulation.
Osmolarity
No information
pH
No information
Endotoxin content
No information
Pfizer
Strength
20 mg/mL in 5mL vial
20 mg/mL in 25mL vial
100 mg/mL in 10mL vial
100 mg/mL in 20mL vial
Excipients
Hydrochloric acid, sodium hydroxide, nitrogen, water for injection, sodium chloride
Osmolarity
No information
pH
No information
Endotoxin content
≤ 0.07 EU/mg
No information available
Products with very little or no information are rarely used for intrathecal administration.
There are currently no known additional cytarabine products.
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